Functional SARS-CoV-2 cross-reactive CD4+ T cells established in early childhood decline with age.

Pre-existing SARS-CoV-2-reactive T cells have been identified in SARS-CoV-2-unexposed individuals, potentially modulating COVID-19 and vaccination outcomes. Here, we provide evidence that functional cross-reactive memory CD4+ T cell immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is established in early childhood, mirroring early seroconversion with seasonal human coronavirus OC43. Humoral and cellular immune responses against OC43 and SARS-CoV-2 were assessed in SARS-CoV-2-unexposed children (paired samples at age two and six) and adults (age 26 to 83). Pre-existing SARS-CoV-2-reactive CD4+ T cell responses targeting spike, nucleocapsid, and membrane were closely linked to the frequency of OC43-specific memory CD4+ T cells in childhood. The functional quality of the cross-reactive memory CD4+ T cell responses targeting SARS-CoV-2 spike, but not nucleocapsid, paralleled OC43-specific T cell responses. OC43-specific antibodies were prevalent already at age two. However, they did not increase further with age, contrasting with the antibody magnitudes against HKU1 (ß-coronavirus), 229E and NL63 (α-coronaviruses), rhinovirus, Epstein-Barr virus (EBV), and influenza virus, which increased after age two. The quality of the memory CD4+ T cell responses peaked at age six and subsequently declined with age, with diminished expression of interferon (IFN)-γ, interleukin (IL)-2, tumor necrosis factor (TNF), and CD38 in late adulthood. Age-dependent qualitative differences in the pre-existing SARS-CoV-2-reactive T cell responses may reflect the ability of the host to control coronavirus infections and respond to vaccination.

Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant.

The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron (B.1.1.529) variant of concern (VOC) has destabilized global efforts to control the impact of coronavirus disease 2019 (COVID-19). Recent data have suggested that B.1.1.529 can readily infect people with naturally acquired or vaccine-induced immunity, facilitated in some cases by viral escape from antibodies that neutralize ancestral SARS-CoV-2. However, severe disease appears to be relatively uncommon in such individuals, highlighting a potential role for other components of the adaptive immune system. We report here that SARS-CoV-2 spike-specific CD4+ and CD8+ T cells induced by prior infection or BNT162b2 vaccination provide extensive immune coverage against B.1.1.529. The median relative frequencies of SARS-CoV-2 spike-specific CD4+ T cells that cross-recognized B.1.1.529 in previously infected or BNT162b2-vaccinated individuals were 84% and 91%, respectively, and the corresponding median relative frequencies for SARS-CoV-2 spike-specific CD8+ T cells were 70% and 92%, respectively. Pairwise comparisons across groups further revealed that SARS-CoV-2 spike-reactive CD4+ and CD8+ T cells were functionally and phenotypically similar in response to the ancestral strain or B.1.1.529. Collectively, our data indicate that established SARS-CoV-2 spike-specific CD4+ and CD8+ T cell responses, especially after BNT162b2 vaccination, remain largely intact against B.1.1.529.

The Language of Risk and Vulnerability in Covering the COVID-19 Pandemic in Swedish Mass Media in 2020: Implications for the Sustainable Management of Elderly Care

The consequences of the COVID-19 pandemic—in terms of climate, economy and social aspects—cannot yet be fully assessed, but we can already see how the pandemic is intensifying already existing socio-economic inequalities. This applies to different population groups, particularly the elderly. In this article, our goal is to identify the linguistic constructions of elderly citizens in Swedish mass media coverage of the COVID-19 pandemic in 2020 from a sociological and corpus linguistics perspective. More specifically, our aim is to explore the discursive formations of the elderly in Swedish media during the pandemic and how these formations relate to risk as well as the discursive constructions of in- and out-groups. Drawing on corpus-assisted discourse studies (CADS), inspired by discourse–historical analysis (DHA), we examine the media coverage of COVID-19 by three Swedish newspapers published during 2020: Aftonbladet, a national tabloid;Svenska Dagbladet, a national morning newspaper;and Dalademokraten, a regional morning newspaper. In this article, the news articles and their messages are considered performative to the extent that—for example, at the same time as a story is expressed—the elderly are at risk of becoming seriously ill due to COVID-19;moreover, a position of vulnerability for the elderly is simultaneously created. The result reveals that the elderly were constructed as an at-risk group, while visitors, personnel and nursing homes were constructed as being risky or a threat to the elderly.

Swedish exceptionalism, herd immunity and the welfare state: A media analysis of struggles over the nature and legitimacy of the COVID-19 pandemic strategy in Sweden

Compared to many other countries, Sweden has managed the COVID-19 pandemic with no lockdowns, less regulation and more voluntary action expected of citizens and organizations. In this article, the authors explore media representations of national preventative strategies and how they were anchored in broader discourses. The article aims to analyse the development of crisis narratives and struggles over legitimacy during the first phase of the COVID-19 pandemic in Sweden. Employing a critical discourse analysis, the authors investigate the editorials and opinion articles in Sweden?s largest morning newspaper, Dagens Nyheter, during the spring of 2020. The authors combine descriptive analyses of the development of the crisis narratives with discursive analyses of conflicting ideologies in the debate. The study indicates that three crisis narratives dominated the debates: health, the economy and democracy. Within and between these narratives, struggles over legitimacy in the handling of COVID-19 were captured in several conflicting perspectives or paradoxes: Swedish exceptionalism versus the world, centralization versus decentralization and herd immunity versus herd humanism.